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Literature summary for 6.3.5.5 extracted from

  • Herve, G.; Nagy, M.; Le Gouar, M.; Penverne, B.; Ladjimi, M.
    The carbamoyl phosphate synthetase-aspartate transcarbamoylase complex of Saccharomyces cerevisiae: molecular and cellular aspects (1993), Biochem. Soc. Trans., 21, 195-198.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
5-phospho-alpha-D-ribosyl 1-diphosphate stimulates Mesocricetus auratus
phosphate multifunctional proteins are phosphorylated in vivo and in vitro. This covalent modification has only a small effect on the enzymic activity, and might be a signal for protein degradation Saccharomyces cerevisiae
phosphate multifunctional proteins are phosphorylated in vivo and in vitro. This covalent modification has only a small effect on the enzymic activity, and might be a signal for protein degradation Mesocricetus auratus

Inhibitors

Inhibitors Comment Organism Structure
UMP feedback inhibition Escherichia coli
UTP
-
Escherichia coli
UTP feed-back inhibition Mesocricetus auratus
UTP feed-back inhibition Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus carbamoyl-phosphate-synthase/aspartate-transcarbamoylase complex Saccharomyces cerevisiae 5634
-

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
eukaryota
-
possess 2 carbamoyl-phosphate synthases, one belonging to the arginine pathway, CPSase-A, and another belonging to the pyrimidine pathway, CPSase-P
-
Mesocricetus auratus
-
multifunctional protein, catalyzing the first three steps in de novo pyrimidine biosynthesis
-
Saccharomyces cerevisiae
-
carbamoyl-phosphate-synthase/aspartate transcarbamoylase complex
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
eukaryota 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?
2 ATP + L-Gln + HCO3-
-
Escherichia coli 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?
2 ATP + L-Gln + HCO3-
-
Saccharomyces cerevisiae 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?
2 ATP + L-Gln + HCO3-
-
Mesocricetus auratus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?

Cofactor

Cofactor Comment Organism Structure
IMP stimulates Escherichia coli