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Literature summary for 6.3.5.5 extracted from

  • Yip, M.C.M.; Knox, W.E.
    Glutamine-dependent carbamyl phosphate synthetase. Properties and distribution in normal and neoplastic rat tissues (1970), J. Biol. Chem., 245, 2199-2204.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
N-acetylglutamate no requirement for N-acetyl-L-glutamate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
6-diazo-5-oxonorleucine
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0119
-
L-Gln
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requires high concentrations of MgATP2- for optimal activity, half-maximal velocity at 10 mM MgATP2- Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
fibrosarcoma cell
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
liver fetal Rattus norvegicus
-
lung
-
Rattus norvegicus
-
mammary carcinoma cell mammary carcinoma DMBA-1C, DMBA-5A, 205A, R3230AC, RNC-211 Rattus norvegicus
-
additional information rapidly growing tissues, e.g. fetal liver, spleen, and testis have much more carbamoyl-phosphate synthase activity than other tissues testes, e.g. lung, uterus, heart, brain and muscle. Tumors are more active than most normal tissues Rattus norvegicus
-
muscle
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
uterus
-
Rattus norvegicus
-
Walker carcinoma 256 cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + L-Gln + HCO3-
-
Rattus norvegicus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
?
2 ATP + NH4+ + HCO3- utilizes NH4+ with 600times lower affinity than Gln Rattus norvegicus 2 ADP + phosphate + carbamoyl phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
with either 5 mM Gln or 100 mM NH4+ as substrate Rattus norvegicus