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Literature summary for 6.3.5.3 extracted from
- Murine gammaherpesvirus 68 open reading frame 75c tegument protein induces the degradation of PML and is essential for production of infectious virus (2008), J. Virol., 82, 8000-8012.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | ORF75c-null viruses are unable to produce infectious virus, the protein may provide essential viral functions in addition to inducing promyelocytic leukemia nuclear body degradation | Murine gammaherpesvirus-68 |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Murine gammaherpesvirus-68 | O41976 | virion tegument protein ORF75c | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | virion tegument protein ORF75c is essential for production of infectious virus.ORF75c induces the rapid degradation of promyelocytic leukemia nuclear body by a proteasome-dependent mechanism and loss of promyelocytic leukemia nuclear body correlates with more robust viral replication. Phosphoribosylformylglycinamidine synthase activity is inferred from electronic annotation | Murine gammaherpesvirus-68 | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ORF75c | - |
Murine gammaherpesvirus-68 |
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Release 2023.1 (January 2023)
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