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Literature summary for 6.3.5.2 extracted from

  • Pegram, L.D.; Megonigal, M.D.; Lange, B.J.; Nowell, P.C.; Rowley, J.D.; Rappaport, E.F.; Felix, C.A.
    t(1;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (guanosine 5' monophosphate synthetase) gene (2000), Blood, 96, 4360-4362.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is essential for de novo purine synthesis. Translocations of the MLL gene at chromosome band 11q23 are prevalent in patients with leukemia after treatment with epipodiphyllotoxins and other DNA topoisomerase II inhibitors. The MLL gene fuses with one of many different partner genes. GMPS is the first partner gene of MLL on chromosome 3Q and the first gene of this type in leukemia-associated translocations ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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with diagnosed metastatic neuroblastoma
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Source Tissue

Source Tissue Comment Organism Textmining
mononuclear cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is essential for de novo purine synthesis. Translocations of the MLL gene at chromosome band 11q23 are prevalent in patients with leukemia after treatment with epipodiphyllotoxins and other DNA topoisomerase II inhibitors. The MLL gene fuses with one of many different partner genes. GMPS is the first partner gene of MLL on chromosome 3Q and the first gene of this type in leukemia-associated translocations Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
GMPS
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Homo sapiens
Guanosine 5'-monophosphate synthetase
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Homo sapiens