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Literature summary for 6.3.5.2 extracted from
- Guanosine monophosphate synthetase from Escherichia coli B-96. Inhibition by nucleosides (1975), J. Biol. Chem., 250, 3101-3107.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,N6-Ethenoadenosine | - |
Escherichia coli |  |
| 1-methyladenosine | - |
Escherichia coli | |
| 2'-deoxyadenosine | - |
Escherichia coli | |
| 2,6-diaminopurine ribonucleoside | - |
Escherichia coli | |
| 2-Amino-6-methylthiopurine ribonucleoside | - |
Escherichia coli | |
| 2-fluoroadenosine | - |
Escherichia coli | |
| 3'-deoxyadenosine | - |
Escherichia coli | |
| 5'-Azido-5'-deoxyadenosine | - |
Escherichia coli | |
| 5'-thioethyl-5'-deoxyadenosine | - |
Escherichia coli | |
| 6-Chloropurine ribonucleoside | - |
Escherichia coli | |
| 6-Methylmercaptopurine ribonucleoside | - |
Escherichia coli | |
| 6-Methylpurine ribonucleoside | - |
Escherichia coli | |
| 6-Methylpurine ribonucleotide | - |
Escherichia coli | |
| 8-azaadenosine | - |
Escherichia coli | |
| 8-Bromoadenosine | - |
Escherichia coli | |
| adenine arabinoside | - |
Escherichia coli | |
| adenosine | - |
Escherichia coli | |
| ADP | - |
Escherichia coli | |
| Decoyinine | - |
Escherichia coli | |
| diphosphate | competitive with respect to ATP; kinetic parameters for the two progressively formed inhibitory complexes | Escherichia coli | |
| Glucofuranosyladenine | - |
Escherichia coli | |
| kinetin ribonucleoside | - |
Escherichia coli | |
| mycophenolate | - |
Escherichia coli | |
| N6,N6-Dimethyladenosine | - |
Escherichia coli | |
| N6-Allyladenosine | - |
Escherichia coli | |
| N6-Benzyladenosine | - |
Escherichia coli | |
| N6-Hydroxyaminopurine ribonucleoside | - |
Escherichia coli | |
| N6-isopentenyladenosine | - |
Escherichia coli | |
| N6-methyladenosine | - |
Escherichia coli | |
| Nucleodide inhibitors | overview | Escherichia coli | |
| tubercidin | - |
Escherichia coli | |
| zeatin ribonucleoside | - |
Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Escherichia coli B96 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + XMP + NH4+ | - |
Escherichia coli | AMP + diphosphate + GMP | - |
? | |
| ATP + XMP + NH4+ | - |
Escherichia coli B96 | AMP + diphosphate + GMP | - |
? | |
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