Protein Variants | Comment | Organism |
---|---|---|
S740I | Chlamydomonas cells bearing a NAD+ synthase mutation have a defective NAD+ de novo synthesis pathway. Mutant cells show longer vegitative life span than wild-type cells. Up-regulation of a sirtuin gene is linked to the extended life span in the mutant strain | Chlamydomonas reinhardtii |
S740I | mutant fails to grow on Sager and Granick rich medium without nicotinamide or Sager and Garnick medium supplemented with 3-acetylpyridine. Mutants grows well on media supplied with either nicotinamide or NMN. Addition of nicotinic acid shows very weak rescue of the nic- mutant phenotype. Addition of 3-hydroxyanthranilate cannot rescue the growth defect. Sirtuin SRT2 levels are 2- to 2.5fold increased in the mutant with concomitant increase in reproductive capactiy | Chlamydomonas reinhardtii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlamydomonas reinhardtii | C4PG67 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
NAD+ synthase | - |
Chlamydomonas reinhardtii |
nic13 | - |
Chlamydomonas reinhardtii |
General Information | Comment | Organism |
---|---|---|
malfunction | a homolog of the human SIRT6-like gene, SRT2, is upregulated in the NAD+ synthase mutant, which shows a longer vegetative life span than wild-type cells | Chlamydomonas reinhardtii |