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Literature summary for 6.3.4.4 extracted from

  • Iancu, C.V.; Zhou, Y.; Borza, T.; Fromm, H.J.; Honzatko, R.B.
    Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases (2006), Biochemistry, 45, 11703-11711.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop method, GDP-2'-deoxy-6-phosphoryl-IMP complex Mus musculus
hanging drop method, GDP-2'-deoxy-6-phosphoryl-IMP-hadacidin complex Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Hadacidin
-
Escherichia coli
Hadacidin
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
L-Asp 22°C, cosubstrate: 2'-dIMP Mus musculus
0.013
-
L-Asp 22°C, cosubstrate: 2'-dIMP Escherichia coli
0.015
-
GTP 22°C, cosubstrate: 2'-dIMP Mus musculus
0.021
-
GTP 22°C, cosubstrate: 2'-dIMP Escherichia coli
0.026
-
GTP 22°C, cosubstrate: IMP Escherichia coli
0.028
-
IMP 22°C Escherichia coli
0.041
-
2'-dIMP 22°C Escherichia coli
0.058
-
2'-dIMP 22°C Mus musculus
0.23
-
L-Asp 22°C, cosubstrate: dIMP Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A7D4
-
-
Mus musculus P28650
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + IMP + L-Asp
-
Escherichia coli GDP + phosphate + adenylosuccinate
-
?
ATP + IMP + L-Asp
-
Mus musculus GDP + phosphate + adenylosuccinate
-
?
GTP + 2'-dIMP + L-Asp
-
Escherichia coli GDP + phosphate + 2'-deoxysuccinoAMP
-
?
GTP + 2'-dIMP + L-Asp
-
Mus musculus GDP + phosphate + 2'-deoxysuccinoAMP
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.96
-
2'-dIMP 22°C Escherichia coli
0.96
-
GTP 22°C, cosubstrate: 2'-dIMP Escherichia coli
0.96
-
L-Asp 22°C, cosubstrate: 2'-dIMP Escherichia coli
1
-
IMP 22°C Escherichia coli
1
-
GTP 22°C, cosubstrate: IMP Escherichia coli
1
-
L-Asp 22°C, cosubstrate: IMP Escherichia coli
5.5
-
2'-dIMP 22°C Mus musculus
5.5
-
GTP 22°C, cosubstrate: 2'-dIMP Mus musculus
5.5
-
L-Asp 22°C, cosubstrate: 2'-dIMP Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00032
-
Hadacidin reaction with IMP Mus musculus
0.00049
-
Hadacidin 22°C, reaction with IMP Escherichia coli
0.014
-
Hadacidin reaction with 2'-dIMP Mus musculus
0.017
-
Hadacidin 22°C, reaction with 2'-dIMP Escherichia coli