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Literature summary for 6.3.4.4 extracted from

  • Raman, J.; Mehrotra, S.; Anand, R.P.; Balaram, H.
    Unique kinetic mechanism of Plasmodium falciparum adenylosuccinate synthetase (2004), Mol. Biochem. Parasitol., 138, 1-8.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
D-fructose 1,6-diphosphate activates Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
adenylosuccinate competitive versus IMP, non-competitive versus GTP and aspartate Plasmodium falciparum
AMP competitive versus IMP, non-competitive versus GTP and non-competitive versus aspartate Plasmodium falciparum
GDP uncompetitive versus IMP, competitive versus GTP and non-competitive versus aspartate Plasmodium falciparum
GMP uncompetitive versus IMP, competitive versus GTP and non-competitive versus aspartate Plasmodium falciparum
Hadacidin uncompetitive versus IMP and GTP, competitive versus aspartate Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0184
-
GTP pH 7.5 Plasmodium falciparum
0.023
-
IMP pH 7.5 Plasmodium falciparum
1.8
-
L-aspartate pH 7.5 Plasmodium falciparum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + IMP + L-aspartate
-
Plasmodium falciparum GDP + phosphate + adenylosuccinate
-
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Synonyms

Synonyms Comment Organism
PfAdSS
-
Plasmodium falciparum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1
-
GTP pH 7.5 Plasmodium falciparum
1.1
-
L-aspartate pH 7.5 Plasmodium falciparum
1.1
-
IMP pH 7.5 Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0053
-
GDP pH 7.5 Plasmodium falciparum
0.019
-
GMP pH 7.5 Plasmodium falciparum
0.029
-
adenylosuccinate pH 7.5 Plasmodium falciparum
0.066
-
AMP pH 7.5 Plasmodium falciparum