Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-fructose 1,6-diphosphate | activates | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenylosuccinate | competitive versus IMP, non-competitive versus GTP and aspartate | Plasmodium falciparum | |
AMP | competitive versus IMP, non-competitive versus GTP and non-competitive versus aspartate | Plasmodium falciparum | |
GDP | uncompetitive versus IMP, competitive versus GTP and non-competitive versus aspartate | Plasmodium falciparum | |
GMP | uncompetitive versus IMP, competitive versus GTP and non-competitive versus aspartate | Plasmodium falciparum | |
Hadacidin | uncompetitive versus IMP and GTP, competitive versus aspartate | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0184 | - |
GTP | pH 7.5 | Plasmodium falciparum | |
0.023 | - |
IMP | pH 7.5 | Plasmodium falciparum | |
1.8 | - |
L-aspartate | pH 7.5 | Plasmodium falciparum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | dependent on | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + IMP + L-aspartate | - |
Plasmodium falciparum | GDP + phosphate + adenylosuccinate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PfAdSS | - |
Plasmodium falciparum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.1 | - |
GTP | pH 7.5 | Plasmodium falciparum | |
1.1 | - |
L-aspartate | pH 7.5 | Plasmodium falciparum | |
1.1 | - |
IMP | pH 7.5 | Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0053 | - |
GDP | pH 7.5 | Plasmodium falciparum | |
0.019 | - |
GMP | pH 7.5 | Plasmodium falciparum | |
0.029 | - |
adenylosuccinate | pH 7.5 | Plasmodium falciparum | |
0.066 | - |
AMP | pH 7.5 | Plasmodium falciparum |