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Literature summary for 6.3.4.4 extracted from
- Adenylosuccinate synthetase of the yeast Saccharomyces cerevisiae: purification and properties (1998), Biochemistry, 63, 650-656.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-amino-4-(N-succinocarboxamide)imidazole ribonucleotide | - |
Saccharomyces cerevisiae |  |
| 5-amino-4-carbamoyl-imidazole ribonucleotide | - |
Saccharomyces cerevisiae | |
| aspartate analogs | - |
Saccharomyces cerevisiae | |
| hydroxylamine | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.16 | - |
GTP | - |
Saccharomyces cerevisiae | |
| 1.7 | - |
IMP | - |
Saccharomyces cerevisiae | |
| 6.7 | - |
L-aspartate | - |
Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + IMP + L-aspartate | Saccharomyces cerevisiae | - |
GDP + phosphate + adenylosuccinate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2'-dGTP + IMP + L-aspartate | - |
Saccharomyces cerevisiae | 2'-dGDP + phosphate + adenylosuccinate | - |
? | |
| ddGTP + IMP + L-aspartate | - |
Saccharomyces cerevisiae | ddGDP + phosphate + adenylosuccinate | - |
? | |
| GTP + IMP + L-aspartate | - |
Saccharomyces cerevisiae | GDP + phosphate + adenylosuccinate | - |
? | |
| GTP + ITP + L-aspartate | - |
Saccharomyces cerevisiae | ? | - |
? | |
| ITP + IMP + L-aspartate | - |
Saccharomyces cerevisiae | IDP + phosphate + adenylosuccinate | - |
? | |
| additional information | ATP cannot be used as substrate instead of GTP | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Adenylosuccinate synthetase | - |
Saccharomyces cerevisiae |
| AS-synthetase | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | - |
- |
Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Saccharomyces cerevisiae |
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