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Literature summary for 6.3.4.4 extracted from

  • Kang, C.; Kim, S.; Fromm, H.J.
    Subunit complementation of Escherichia coli adenylosuccinate synthetase (1996), J. Biol. Chem., 271, 29722-29728.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
R143L although the mutants R143L and D13A have low or no activity independently, when they are mixed, a significant amount of activity is obtained. These results indicate that the subunits exchange with each other to form heterodimers with a single viable active site Escherichia coli

General Stability

General Stability Organism
GTP and IMP stabilize the dimeric structure Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
wild-type and mutant enzymes R143L and D13A
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + IMP + L-Asp
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Escherichia coli GDP + phosphate + adenylosuccinate
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