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Literature summary for 6.3.4.4 extracted from

  • Stayton, M.M.; Rudolph, F.B.; Fromm, H.J.
    Regulation, genetics, and properties of adenylosuccinate synthetase (1983), Curr. Top. Cell. Regul., 22, 103-141.
    View publication on PubMed
Search for more literature for 6.3.4.4

Inhibitors

Inhibitors Comment Organism Structure
6-mercaptopurine riboside 5'-phosphate
-
 Escherichia coli
adenylosuccinate
-
 Escherichia coli
adenylosuccinate
-
 Homo sapiens
adenylosuccinate
-
 Oryctolagus cuniculus
adenylosuccinate
-
 Rattus norvegicus
beta,gamma-5'-Guanylylmethylene diphosphate
-
 Escherichia coli
fructose 1,6-diphosphate
-
 Oryctolagus cuniculus
fructose 1,6-diphosphate basic type M isozym more strongly inhibited than acidic type L isozym Rattus norvegicus
GDP
-
 Escherichia coli
GDP
-
 Homo sapiens
GDP
-
 Oryctolagus cuniculus
GDP
-
 Rattus norvegicus
Hadacidin
-
 Azotobacter vinelandii
Hadacidin
-
 Escherichia coli
Hadacidin
-
 Rattus norvegicus
additional information overview Azotobacter vinelandii
additional information overview Bacillus subtilis
additional information overview Escherichia coli
additional information overview Gallus gallus
additional information overview Homo sapiens
additional information overview Leishmania donovani
additional information overview Oryctolagus cuniculus
additional information overview Rattus norvegicus
additional information overview Schizosaccharomyces pombe
additional information overview Sus scrofa
additional information overview Triticum aestivum
additional information overview Trypanosoma cruzi
nucleotides acidic type L isozyme more strongly inhibited than basic type M isozyme Rattus norvegicus
succinate
-
 Azotobacter vinelandii
succinate
-
 Escherichia coli
succinate
-
 Homo sapiens
succinate
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004 0.38 GTP muscle enzyme Rattus norvegicus
0.01 0.048 GTP
-
 Escherichia coli
0.01 0.012 GTP
-
 Oryctolagus cuniculus
0.011
-
 GTP
-
 Sus scrofa
0.012
-
 GTP muscle enzyme Gallus gallus
0.012
-
 GTP IMP Leishmania donovani
0.013
-
 IMP
-
 Azotobacter vinelandii
0.015
-
 GTP
-
 Azotobacter vinelandii
0.015 0.13 GTP liver acidic type L isozyme Rattus norvegicus
0.017
-
 GTP liver enzyme Gallus gallus
0.018
-
 GTP heart enzyme Rattus norvegicus
0.02
-
 GTP
-
 Schizosaccharomyces pombe
0.02
-
 GTP Asp, liver enzyme Gallus gallus
0.02
-
 GTP IMP, liver enzyme Gallus gallus
0.02 0.2 IMP
-
 Escherichia coli
0.03
-
 Asp
-
 Escherichia coli
0.03
-
 Asp muscle enzyme Gallus gallus
0.03 0.32 IMP liver acidic type L isozyme Rattus norvegicus
0.031 0.072 GTP
-
 Homo sapiens
0.034
-
 IMP
-
 Azotobacter vinelandii
0.037 0.07 IMP
-
 Schizosaccharomyces pombe
0.047
-
 IMP
-
 Escherichia coli
0.073
-
 GTP
-
 Azotobacter vinelandii
0.09
-
 GTP IMP Triticum aestivum
0.09
-
 GTP liver basic type L isozyme Rattus norvegicus
0.107 0.2 IMP
-
 Oryctolagus cuniculus
0.167
-
 IMP heart enzyme Rattus norvegicus
0.171
-
 IMP muscle enzyme Gallus gallus
0.2
-
 IMP
-
 Oryctolagus cuniculus
0.2
-
 IMP
-
 Schizosaccharomyces pombe
0.2 0.7 IMP muscle enzyme Rattus norvegicus
0.23
-
 Asp
-
 Escherichia coli
0.23
-
 Asp
-
 Sus scrofa
0.25 0.36 Asp muscle enzyme Rattus norvegicus
0.29 0.3 Asp
-
 Oryctolagus cuniculus
0.308
-
 Asp
-
 Escherichia coli
0.308
-
 Asp heart enzyme Rattus norvegicus
0.33
-
 Asp
-
 Oryctolagus cuniculus
0.33
-
 Asp liver basic type L isozyme Rattus norvegicus
0.36 1.47 Asp acidic liver type L isozym Rattus norvegicus
0.43
-
 Asp
-
 Triticum aestivum
0.43
-
 Asp
-
 Leishmania donovani
0.5
-
 Asp
-
 Azotobacter vinelandii
0.68
-
 Asp
-
 Bacillus subtilis
0.69
-
 IMP liver basic isozyme Rattus norvegicus
0.7
-
 IMP skeletal muscle Rattus norvegicus
0.95 1.16 Asp
-
 Homo sapiens
1.5
-
 Asp
-
 Schizosaccharomyces pombe

Metals/Ions

Metals/Ions Comment Organism Structure
additional information
-
 Gallus gallus
additional information
-
 Bacillus subtilis
additional information
-
 Escherichia coli
additional information
-
 Homo sapiens
additional information
-
 Rattus norvegicus
additional information
-
 Sus scrofa
additional information
-
 Triticum aestivum
additional information
-
 Oryctolagus cuniculus
additional information
-
 Schizosaccharomyces pombe
additional information
-
 Leishmania donovani
additional information
-
 Azotobacter vinelandii
additional information
-
 Trypanosoma cruzi

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000 60000 liver and Novikoff ascites cells Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Azotobacter vinelandii
-
-
-
Bacillus subtilis
-
-
-
Escherichia coli
-
-
-
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Leishmania donovani
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
 2 isozymic forms: acidic type L, and basic type M
-
Schizosaccharomyces pombe
-
-
-
Sus scrofa
-
-
-
Triticum aestivum
-
-
-
Trypanosoma cruzi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
heart
-
 Oryctolagus cuniculus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Oryctolagus cuniculus
-
additional information tissue distribution of L-isozyme and M-isozyme Rattus norvegicus
-
muscle
-
 Rattus norvegicus
-
muscle
-
 Oryctolagus cuniculus
-
Novikoff ascites tumor cell
-
 Rattus norvegicus
-
placenta
-
 Homo sapiens
-
spleen
-
 Rattus norvegicus
-
Yoshida ascites sarcoma cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + 2'-dIMP + L-Asp
-
 Oryctolagus cuniculus GDP + phosphate + 2'-deoxysuccinoAMP
-
 ?
GTP + 2'-dIMP + L-Asp
-
 Leishmania donovani GDP + phosphate + 2'-deoxysuccinoAMP
-
 ?
GTP + 2'-dIMP + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + 2'-deoxysuccinoAMP
-
 ?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
-
 Leishmania donovani GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
-
 ?
GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
-
 ?
GTP + 8-azaIMP + L-Asp
-
 Leishmania donovani GDP + phosphate + 8-azasuccinoAMP
-
 ?
GTP + 8-azaIMP + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + 8-azasuccinoAMP
-
 ?
GTP + beta-D-arabinosylIMP + L-Asp
-
 Oryctolagus cuniculus GDP + phosphate + arabinosylsuccinoAMP
-
 ?
GTP + beta-D-arabinosylIMP + L-Asp
-
 Leishmania donovani GDP + phosphate + arabinosylsuccinoAMP
-
 ?
GTP + beta-D-arabinosylIMP + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + arabinosylsuccinoAMP
-
 ?
GTP + IMP + L-Asp
-
 Gallus gallus GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Bacillus subtilis GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Escherichia coli GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Homo sapiens GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Rattus norvegicus GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Sus scrofa GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Triticum aestivum GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Oryctolagus cuniculus GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Schizosaccharomyces pombe GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Leishmania donovani GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Azotobacter vinelandii GDP + phosphate + adenylosuccinate
-
 ?
GTP + IMP + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + adenylosuccinate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7 8.7
-
 Leishmania donovani