Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.4.21 extracted from

  • Hayakawa, T.; Shibata, K.; Iwai, K.
    Nicotinate phosphoribosyltransferase from hog liver: regulatory effect of ATP at a physiological concentrations of 5-phosphoribosyl-1-pyrophosphte (1984), Agric. Biol. Chem., 48, 455-460.
No PubMed abstract available
Search for more literature for 6.3.4.21

General Stability

General Stability Organism
dialysis against 50 mM Tris-HCl buffer at pH 7.3 in the absence of potassium phosphate, significant loss of activity Rattus norvegicus
dialysis against 50 mM Tris-HCl buffer at pH 7.3 in the absence of potassium phosphate, significant loss of activity Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
 5-phospho-alpha-D-ribose 1-diphosphate reduced to 0.002 mM in the presence of ATP Rattus norvegicus
0.013
-
 5-phospho-alpha-D-ribose 1-diphosphate reduced to 0.002 mM in the presence of ATP Sus scrofa
0.22
-
 nicotinate reduced to 0.053 mM in the presence of ATP Rattus norvegicus
0.22
-
 nicotinate reduced to 0.053 mM in the presence of ATP Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
phosphate markedly stimulates even in the absence of ATP Rattus norvegicus
phosphate markedly stimulates even in the absence of ATP Sus scrofa

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Rattus norvegicus beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Sus scrofa beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
NPRTase
-
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus
37
-
 assay at Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP activation Rattus norvegicus
ATP activation Sus scrofa
ATP requirement in the absence of phosphate Sus scrofa