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Literature summary for 6.3.4.21 extracted from

  • Gaut, Z.N.; Solomon, H.M.
    Inhibition of nicotinate phosphoribosyltransferase in human platelet lysate by nicotinic acid analogs (1971), Biochem. Pharmacol., 20, 2903-2906.
    View publication on PubMed
Search for more literature for 6.3.4.21

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by 4-hydroxy-nicotinate Homo sapiens
Nicotinate analogues
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
 nicotinate
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Homo sapiens
Mg2+ synergism with ATP Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information one mol ATP is cleaved per mol product formed Homo sapiens ?
-
 ?
additional information no ATPase activity in the absence of substrates Homo sapiens ?
-
 ?
nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O the pyridine N and carboxyl groups are important for interaction with the enzyme Homo sapiens beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP 1 mol ATP is hydrolyzed to ADP plus phosphate per mol product formed Homo sapiens
ATP together with Mg2+ Homo sapiens