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Literature summary for 6.3.4.20 extracted from

  • Phillips, G.; Swairjo, M.A.; Gaston, K.W.; Bailly, M.; Limbach, P.A.; Iwata-Reuyl, D.; de Crecy-Lagard, V.
    Diversity of archaeosine synthesis in crenarchaeota (2012), ACS Chem. Biol., 7, 300-305.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Crenarchaeota
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-
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Synonyms

Synonyms Comment Organism
queC
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Crenarchaeota

General Information

General Information Comment Organism
evolution the enzyme belongs to GAT-QueC, a two-domain family with an N-terminal glutamine amidotransferase class-II domain fused to a domain homologous to QueC, the enzyme that produces preQ0. Phylogenetic distribution of aTGT, ArcS, GAT-QueC, and QueF-like in the two archaeal phyla, overview. Most crenarchaeal genomes encode a fused GAT-QueC protein or a QueF-like protein Crenarchaeota
physiological function the enzyme QueC produces the G+ precursor, 7-cyano-7-deazaguanine, i.e. preQ0, which is inserted into tRNA by tRNA-guanine transglycosylase before conversion into G+ by archaeosine synthase, ArcS. Gat-QueC and QueF-like families can compensate for lack of ArcS, overview Crenarchaeota