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Literature summary for 6.3.4.19 extracted from

  • Soma, A.; Ikeuchi, Y.; Kanemasa, S.; Kobayashi, K.; Ogasawara, N.; Ote, T.; Kato, J.; Watanabe, K.; Sekine, Y.; Suzuki, T.
    An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA (2003), Mol. Cell, 12, 689-698.
    View publication on PubMed
Search for more literature for 6.3.4.19

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli
-
 Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[tRNAIle2]-cytidine34 + L-lysine + ATP Escherichia coli the enzyme generates lysidine at the wobble position of tRNAIle. The enzyme is essential for the decoding of AUA codons in the cell [tRNAIle2]-2-L-lysylcytidine34 + AMP + diphosphate
-
 ?
[tRNAIle2]-cytidine34 + L-lysine + ATP Bacillus subtilis the enzyme generates lysidine at the wobble position of tRNAIle. The enzyme is essential for the decoding of AUA codons in the cell [tRNAIle2]-2-L-lysylcytidine34 + AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis P37563
-
-
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli
-
 Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[tRNAIle2]-cytidine34 + L-lysine + ATP the enzyme generates lysidine at the wobble position of tRNAIle. The enzyme is essential for the decoding of AUA codons in the cell Escherichia coli [tRNAIle2]-2-L-lysylcytidine34 + AMP + diphosphate
-
 ?
[tRNAIle2]-cytidine34 + L-lysine + ATP the enzyme generates lysidine at the wobble position of tRNAIle. The enzyme is essential for the decoding of AUA codons in the cell Bacillus subtilis [tRNAIle2]-2-L-lysylcytidine34 + AMP + diphosphate
-
 ?
[tRNAIle2]-cytidine34 + L-lysine + ATP lysidine synthesis TilS directly converts the amino acid specificity from methionine to isoleucine in vitro Escherichia coli [tRNAIle2]-2-L-lysylcytidine34 + AMP + diphosphate
-
 ?
[tRNAIle2]-cytidine34 + L-lysine + ATP lysidine synthesis TilS directly converts the amino acid specificity from methionine to isoleucine in vitro Bacillus subtilis [tRNAIle2]-2-L-lysylcytidine34 + AMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
mesJ
-
 Escherichia coli
mesJ
-
 Bacillus subtilis
TilS protein
-
 Escherichia coli
TilS protein
-
 Bacillus subtilis

General Information

General Information Comment Organism
malfunction partial inactivation of tilS in vivo results in an AUA codon-dependent translational defect Escherichia coli
malfunction partial inactivation of tilS in vivo results in an AUA codon-dependent translational defect Bacillus subtilis
physiological function the enzyme generates lysidine at the wobble position of tRNAIle. The enzyme is essential for the decoding of AUA codons in the cell Escherichia coli
physiological function the enzyme generates lysidine at the wobble position of tRNAIle. The enzyme is essential for the decoding of AUA codons in the cell Bacillus subtilis