Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-formyltetrahydrofolate polyglutamate | induced recombinant enzyme expression in cancer cell cultures, increasing effect with increasing chain length | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in MCF-7 mammary adenocarcinoma cell line and in SH-SY5Y neuroblastoma cell line | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5-formyltetrahydrofolate | Mus musculus | - |
ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
? | |
ATP + 5-formyltetrahydrofolate | Homo sapiens | enzyme plays an important role in one-carbon metabolism, overview about folate catabolism | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | low enzyme expression | Mus musculus | - |
embryo | moderate enzyme expression | Mus musculus | - |
heart | low enzyme expression | Mus musculus | - |
kidney | moderate enzyme expression | Mus musculus | - |
liver | highest enzyme expression | Mus musculus | - |
lung | low enzyme expression | Mus musculus | - |
additional information | tissue specific expression | Homo sapiens | - |
ovary | moderate enzyme expression | Mus musculus | - |
spleen | low enzyme expression | Mus musculus | - |
testis | low enzyme expression | Mus musculus | - |
thymus | moderate enzyme expression | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity of recombinantly expressed enzyme in different cell cultures | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5-formyltetrahydrofolate | - |
Mus musculus | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
? | |
ATP + 5-formyltetrahydrofolate | enzyme prefers the polyglutamate forms of the substrate compared to the monoglutamate form | Homo sapiens | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
ir | |
ATP + 5-formyltetrahydrofolate | enzyme plays an important role in one-carbon metabolism, overview about folate catabolism | Homo sapiens | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
Methenyltetrahydrofolate synthetase | - |
Mus musculus |
Methenyltetrahydrofolate synthetase | - |
Homo sapiens |
MTHFS | - |
Mus musculus |
MTHFS | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |