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Literature summary for 6.3.2.9 extracted from

  • Tomasic, T.; Zidar, N.; Sink, R.; Kovac, A.; Blanot, D.; Contreras-Martel, C.; Dessen, A.; Muller-Premru, M.; Zega, A.; Gobec, S.; Kikelj, D.; Peterlin Masic, L.
    Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-l-alanine:d-glutamate ligase (MurD) (2011), J. Med. Chem., 54, 4600-4610.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
moelcular docking of inhibitor 6_3_2-9_4-R16 Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
(R,Z)-2-(3-((1-carboxy-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)-methyl)phenyl)formamido)methyl)benzamido)pentanedioic acid
-
Escherichia coli
(R,Z)-2-(3-((2-carboxy-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)-methyl)phenyl)acetamido)methyl)benzamido)pentanedioic acid in addition, weak activity against Gram-positive Staphylococcus aureus and Enterococcus faecalis Escherichia coli
(R,Z)-2-(3-((3-carboxy-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)-methyl)phenyl)propanamido)methyl)benzamido)pentanedioic acid in addition, weak activity against Gram-positive Staphylococcus aureus and Enterococcus faecalis Escherichia coli
N-(3-[[(carboxyacetyl)[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl]amino]methyl]benzoyl)-D-glutamic acid
-
Escherichia coli
N-[2-fluoro-5-[([4-[(Z)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl]amino)methyl]benzoyl]-D-glutamic acid
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P14900
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
pH not specified in the publication, temperature not specified in the publication. Malachite green assay in presence of 0.01% Triton X-100 Escherichia coli (R,Z)-2-(3-((2-carboxy-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)-methyl)phenyl)acetamido)methyl)benzamido)pentanedioic acid
0.005
-
pH not specified in the publication, temperature not specified in the publication. Malachite green assay in presence of 0.01% Triton X-100 Escherichia coli (R,Z)-2-(3-((1-carboxy-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)-methyl)phenyl)formamido)methyl)benzamido)pentanedioic acid
0.007
-
pH not specified in the publication, temperature not specified in the publication. Malachite green assay in presence of 0.01% Triton X-100 Escherichia coli (R,Z)-2-(3-((3-carboxy-N-(4-((4-oxo-2-thioxothiazolidin-5-ylidene)-methyl)phenyl)propanamido)methyl)benzamido)pentanedioic acid
0.015
-
pH not specified in the publication, temperature not specified in the publication. Malachite green assay in presence of 0.01% Triton X-100 Escherichia coli N-(3-[[(carboxyacetyl)[4-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl]amino]methyl]benzoyl)-D-glutamic acid
0.252
-
pH not specified in the publication, temperature not specified in the publication. Malachite green assay in presence of 0.01% Triton X-100 Escherichia coli N-[2-fluoro-5-[([4-[(Z)-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl]amino)methyl]benzoyl]-D-glutamic acid