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Literature summary for 6.3.2.9 extracted from
- Virtual screening for potential inhibitors of homology modeled Leptospira interrogans MurD ligase (2010), J. Chem. Biol., 13, 175-187.
No PubMed abstract available
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| generation of MurD 3D models using crystal structures of PDB entries 1EEH and 2JFF as templates in Modeller9v7 | Leptospira interrogans |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | generation of MurD 3D models using crystal structures of PDB entries 1EEH and 2JFF as templates in Modeller9v7 and generation of an in-house library of 1,496 MurD inhibitor analogs. Virtual screening of the best-ranked compounds with pharmacokinetics property prediction has provided 17 MurD inhibitors for developing anti-leptospirosis drug targeting peptidoglycan biosynthesis pathway | Leptospira interrogans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leptospira interrogans | Q8F7V4 | - |
- |
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