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Literature summary for 6.3.2.6 extracted from

  • Ginder, N.D.; Binkowski, D.J.; Fromm, H.J.; Honzatko, R.B.
    Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase (2006), J. Biol. Chem., 281, 20680-20688.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor diffusion, crystal structures of the ADP and the ADP/4-carboxy-5-aminoimidazole ribonucleotide complexes of SAICAR synthetase. ADP and 4-carboxy-5-aminoimidazole ribonucleotide bind to the active site in association with three Mg2+, two of which coordinate the same oxygen atom of the 4-carboxyl group of CAIR, whereas, the third coordinates the alpha- and beta-phosphoryl groups of ADP. The polypeptide fold for residues 204-221 of the Escherichia coli structure differs significantly from those of the ligand-free SAICAR synthetase from Thermatoga maritima and the adenine nucleotide complexes of the synthetase from Saccharomyces cerevisiae Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A7D7
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
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Escherichia coli ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
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Synonyms

Synonyms Comment Organism
phosphoribosylaminoimidazole succinocarboxamide synthetase
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Escherichia coli