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Literature summary for 6.3.2.4 extracted from

  • Halouska, S.; Fenton, R.; Zinniel, D.; Marshall, D.; Barletta, R.; Powers, R.
    Metabolomics analysis identifies D-alanine-D-alanine ligase as the primary lethal target of D-cycloserine in mycobacteria (2014), J. Proteome Res., 13, 1065-1076.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
D-cycloserine interferes with the formation of peptidoglycan biosynthesis by competitive inhibition of alanine racemase and D-alanine-D-alanine ligase, the latter is the primary lethal target, inhibition mechanism and physiological effects, NMR metabolomic study, overview. D-Alanine is able to effectively compete with the inhibitor for uptake Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2 D-alanine Mycobacterium tuberculosis
-
ADP + phosphate + D-alanyl-D-alanine
-
?
ATP + 2 D-alanine Mycobacterium tuberculosis H37Rv
-
ADP + phosphate + D-alanyl-D-alanine
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2 D-alanine
-
Mycobacterium tuberculosis ADP + phosphate + D-alanyl-D-alanine
-
?
ATP + 2 D-alanine
-
Mycobacterium tuberculosis H37Rv ADP + phosphate + D-alanyl-D-alanine
-
?

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mycobacterium tuberculosis

General Information

General Information Comment Organism
additional information NMR ligand binding assay for D-alanine-D-alanine ligase, overview Mycobacterium tuberculosis