Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-cycloserine | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Ala + Ala | Escherichia coli | a possible cellular role of VanA is to synthesize a modified cell-wall component, with D-Ala-D-Met or D-Ala-Phe instead of D-Ala-D-Ala, which is subsequently not recognized by vancomycin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
containing recombinant plasmid pAT214, which expressed the VanA protein | - |
Escherichia coli JM105 | - |
containing recombinant plasmid pAT214, which expressed the VanA protein | - |
Purification (Comment) | Organism |
---|---|
Van A | Escherichia coli |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
7.9 | - |
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Ala + Ala | a possible cellular role of VanA is to synthesize a modified cell-wall component, with D-Ala-D-Met or D-Ala-Phe instead of D-Ala-D-Ala, which is subsequently not recognized by vancomycin | Escherichia coli | ? | - |
? | |
ATP + D-Ala + D-2-aminopentanoate | - |
Escherichia coli | ADP + phosphate + D-Ala-D-2-aminopentanoate | - |
? | |
ATP + D-Ala + D-2-aminopentanoate | - |
Escherichia coli JM105 | ADP + phosphate + D-Ala-D-2-aminopentanoate | - |
? | |
ATP + D-Ala + D-Ala | - |
Escherichia coli | ADP + phosphate + D-Ala-D-Ala | - |
? | |
ATP + D-Ala + D-Ala | - |
Escherichia coli JM105 | ADP + phosphate + D-Ala-D-Ala | - |
? | |
ATP + D-Ala + D-Met | - |
Escherichia coli | ADP + phosphate + D-Ala-D-Met | - |
? | |
ATP + D-Ala + D-Met | - |
Escherichia coli JM105 | ADP + phosphate + D-Ala-D-Met | - |
? | |
ATP + D-Ala + D-norleucine | - |
Escherichia coli | ADP + phosphate + D-Ala-D-norleucine | - |
? | |
ATP + D-Ala + D-norleucine | - |
Escherichia coli JM105 | ADP + phosphate + D-Ala-D-norleucine | - |
? | |
ATP + D-Ala + D-Phe | - |
Escherichia coli | ADP + phosphate + D-Ala-D-Phe | - |
? | |
ATP + D-Ala + D-Phe | - |
Escherichia coli JM105 | ADP + phosphate + D-Ala-D-Phe | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.92 | - |
D-Ala | - |
Escherichia coli |