Literature summary for 6.3.2.10 extracted from

Turk, S.; Kovac, A.; Boniface, A.; Bostock, J.M.; Chopra, I.; Blanot, D.; Gobec, S.
Discovery of new inhibitors of the bacterial peptidoglycan biosynthesis enzymes MurD and MurF by structure-based virtual screening (2009), Bioorg. Med. Chem., 17, 1884-1889.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-[(pentachlorobenzyl)sulfanyl]-6-sulfanyl-1,3,5-triazin-2-ol	i.e. NSC 209931, inhibitor identified by structure-based virtual screening	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-diaminopimelic acid + D-alanyl-D-alanine	-	Escherichia coli	ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-diaminopimeloyl-D-alanyl-D-alanine	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.063	-	pH 8.0, 37°C	Escherichia coli	4-[(pentachlorobenzyl)sulfanyl]-6-sulfanyl-1,3,5-triazin-2-ol

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Release 2023.1 (January 2023)