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Literature summary for 6.3.1.2 extracted from

  • Gising, J.; Nilsson, M.T.; Odell, L.R.; Yahiaoui, S.; Lindh, M.; Iyer, H.; Sinha, A.M.; Srinivasa, B.R.; Larhed, M.; Mowbray, S.L.; Karlen, A.
    Trisubstituted imidazoles as Mycobacterium tuberculosis glutamine synthetase inhibitors (2012), J. Med. Chem., 55, 2894-2898.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-amino-4-(S-methyl-N-phosphonosulfonimidoyl)butanoic acid
-
Mycobacterium tuberculosis
(2S)-2-amino-4-(S-methylsulfonimidoyl)butanoic acid
-
Mycobacterium tuberculosis
2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-5-phenyl-1H-imidazole
-
Mycobacterium tuberculosis
2-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyrimidine
-
Mycobacterium tuberculosis
3-[2-tert-butyl-5-(pyridin-4-yl)-1H-imidazol-4-yl]quinoline
-
Mycobacterium tuberculosis
3-[4-(6-methoxynaphthalen-2-yl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
-
Mycobacterium tuberculosis
4-(2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl)pyridin-2-amine
-
Mycobacterium tuberculosis
4-[2-ethyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
-
Mycobacterium tuberculosis
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]-2-fluoropyridine
-
Mycobacterium tuberculosis
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]-N,N-dimethylpyridin-2-amine
-
Mycobacterium tuberculosis
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]-N-methylpyridin-2-amine
-
Mycobacterium tuberculosis
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridin-2(1H)-one
-
Mycobacterium tuberculosis
4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
-
Mycobacterium tuberculosis
4-[4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
-
Mycobacterium tuberculosis
4-[4-(6-methoxynaphthalen-2-yl)-2-(1H-pyrrol-2-yl)-1H-imidazol-5-yl]pyridine
-
Mycobacterium tuberculosis
4-[4-(6-methoxynaphthalen-2-yl)-2-(2-phenylpropan-2-yl)-1H-imidazol-5-yl]pyridine
-
Mycobacterium tuberculosis
4-[4-(6-methoxynaphthalen-2-yl)-2-(phenoxymethyl)-1H-imidazol-5-yl]pyridine
-
Mycobacterium tuberculosis
4-[4-(6-methoxynaphthalen-2-yl)-2-methyl-1H-imidazol-5-yl]pyridine
-
Mycobacterium tuberculosis
4-[4-(6-methoxynaphthalen-2-yl)-2-phenyl-1H-imidazol-5-yl]pyridine
-
Mycobacterium tuberculosis
5-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyrimidine
-
Mycobacterium tuberculosis
additional information synthesis and inhibitory potency of 2-tert-butyl-4,5-diarylimidazoles inhibitors, overview. No inhibition by 4-[4-(6-methoxynaphthalen-2-yl)-2-(phenoxymethyl)-1H-imidazol-5-yl]pyridine and [4-(6-methoxynaphthalen-2-yl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]methanol Mycobacterium tuberculosis
[4-(6-methoxynaphthalen-2-yl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]methanol
-
Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Synonyms

Synonyms Comment Organism
Glutamine synthetase
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
pH and temperature not specified in the publication Mycobacterium tuberculosis 3-[2-tert-butyl-5-(pyridin-4-yl)-1H-imidazol-4-yl]quinoline
0.0012
-
pH and temperature not specified in the publication Mycobacterium tuberculosis 4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]-2-fluoropyridine
0.0022
-
pH and temperature not specified in the publication Mycobacterium tuberculosis 4-[2-ethyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
0.0031
-
pH and temperature not specified in the publication Mycobacterium tuberculosis 4-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
0.025
-
above, pH and temperature not specified in the publication Mycobacterium tuberculosis 2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-5-phenyl-1H-imidazole
0.025
-
above, pH and temperature not specified in the publication Mycobacterium tuberculosis 2-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyrimidine
0.025
-
above, pH and temperature not specified in the publication Mycobacterium tuberculosis 3-[4-(6-methoxynaphthalen-2-yl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
0.025
-
above, pH and temperature not specified in the publication Mycobacterium tuberculosis 4-[4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyridine
0.025
-
above, pH and temperature not specified in the publication Mycobacterium tuberculosis 4-[4-(6-methoxynaphthalen-2-yl)-2-(1H-pyrrol-2-yl)-1H-imidazol-5-yl]pyridine
0.025
-
above, pH and temperature not specified in the publication Mycobacterium tuberculosis 4-[4-(6-methoxynaphthalen-2-yl)-2-(2-phenylpropan-2-yl)-1H-imidazol-5-yl]pyridine
0.025
-
above, pH and temperature not specified in the publication Mycobacterium tuberculosis 4-[4-(6-methoxynaphthalen-2-yl)-2-methyl-1H-imidazol-5-yl]pyridine
0.025
-
above, pH and temperature not specified in the publication Mycobacterium tuberculosis 4-[4-(6-methoxynaphthalen-2-yl)-2-phenyl-1H-imidazol-5-yl]pyridine
0.025
-
above, pH and temperature not specified in the publication Mycobacterium tuberculosis 5-[2-tert-butyl-4-(6-methoxynaphthalen-2-yl)-1H-imidazol-5-yl]pyrimidine