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Literature summary for 6.3.1.2 extracted from
- Chronic exposure to glufosinate-ammonium induces spatial memory impairments, hippocampal MRI modifications and glutamine synthetase activation in mice (2008), Neurotoxicology, 29, 740-747.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-glutamate + NH3 | Mus musculus | the enzyme plays a pivotal role in the mammalian brain where it allows neurotransmitter glutamate recycling within astroglia | ADP + phosphate + L-glutamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
male C57BL/6J mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Mus musculus | - |
| brain | - |
Mus musculus | - |
| glial cell | - |
Mus musculus | - |
| hippocampus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-glutamate + hydroxylamine | photometric determination of GS activity based on formation of an L-gamma-glutamylhydroxamate ferric chloride complex using hydroxylamine instead of ammonia | Mus musculus | ADP + phosphate + L-gamma-glutamylhydroxamate | - |
? | |
| ATP + L-glutamate + NH3 | - |
Mus musculus | ADP + phosphate + L-glutamine | - |
? | |
| ATP + L-glutamate + NH3 | the enzyme plays a pivotal role in the mammalian brain where it allows neurotransmitter glutamate recycling within astroglia | Mus musculus | ADP + phosphate + L-glutamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Glutamine synthetase | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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