Application | Comment | Organism |
---|---|---|
diagnostics | glutamine synthetase is a useful marker in tumour liver pathology, including hepatocellular adenomas and nodules in cirrhosis. Enzyme overexpression in focal nodular hyperplasia can be used as easy diagnostic tool in surgical pathology | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | Homo sapiens | - |
ADP + phosphate + L-glutamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | the enzyme expression pattern is completely different form the healthy cell pattern and appears diffuse and not map-like | Homo sapiens | - |
hepatocyte | - |
Homo sapiens | - |
liver | the cytosolic enzyme is localized in large areas, anastomosed in a map-like pattern, often surrounding hepatic veins, whereas GS is not expressed in hepatocytes close to fibrotic bands containing arteries and ductules | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | - |
Homo sapiens | ADP + phosphate + L-glutamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glutamine synthetase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |