Application | Comment | Organism |
---|---|---|
medicine | restoration of glutamine synthetase may represent an approach to therapeutic intervention in mesial temporal lobe epilepsy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methionine sulfoximine | - |
Homo sapiens | |
methionine sulfoximine | irreversible inhibition up to 97% in vivo after longterm treatment over 3 h by Intracranial infusion | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | Homo sapiens | - |
ADP + phosphate + L-glutamine | - |
? | |
ATP + L-glutamate + NH3 | Rattus norvegicus | - |
ADP + phosphate + L-glutamine | - |
? | |
additional information | Rattus norvegicus | deficiency in hippocampal glutamine synthetase causes recurrent seizures, even in the absence of classical mesial temporal sclerosis, overview | ? | - |
? | |
additional information | Homo sapiens | extracellular glutamate in the hippocampus causes recurrent seizures and is involved in medically intractable mesial temporal lobe epilepsy, MTLE, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
male Sprague Dawley rats | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
hippocampus | - |
Homo sapiens | - |
hippocampus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | - |
Homo sapiens | ADP + phosphate + L-glutamine | - |
? | |
ATP + L-glutamate + NH3 | - |
Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? | |
additional information | deficiency in hippocampal glutamine synthetase causes recurrent seizures, even in the absence of classical mesial temporal sclerosis, overview | Rattus norvegicus | ? | - |
? | |
additional information | extracellular glutamate in the hippocampus causes recurrent seizures and is involved in medically intractable mesial temporal lobe epilepsy, MTLE, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glutamine synthetase | - |
Homo sapiens |
Glutamine synthetase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |