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Literature summary for 6.2.1.45 extracted from
- Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo (2000), Eur. J. Biochem., 267, 3712-3722.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A31N-ts20 cell | mouse embryo fibroblast cell, thermosensitive for ubiquitin-activating enzyme E1 | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| E1 ubiquitin-activating enzyme | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in mouse embryo fibroblast cell A31N-ts20, which is thermosensitive for ubiquitin-activating enzyme E1, the enzymatic activity of the enzyme is heat-inactivatable in vitro; and a major mechanism responsible for E1 inactivation in vivo consists of accelerated destruction. In vivo, ubiquitination of the various protein substrates in A31N-ts20 cells requires different amounts of E1 enzyme | Mus musculus |
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