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Literature summary for 6.2.1.3 extracted from
- Molecular characterization and expression of rat acyl-CoA synthetase 3 (1996), J. Biol. Chem., 271, 16748-16752.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ACS3, one of multiple forms of enzyme in brain, expression in COS cells | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00053 | - |
CoA | - |
Rattus norvegicus |  |
| 0.5 | - |
ATP | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + long-chain carboxylic acid + CoA | Rattus norvegicus | the presence in the brain of multiple forms of enzyme with different fatty acid specificity is of considerable biological significance for controlling the synthesis of brain lipids. ACS3 mRNA is detectable 5 days after birth, increases to a maximum level at 15 days, and then decreases gradually to 10% of its maximum level in the adult | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q63151 | ACS3, one of multiple form of the enzyme in brain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ACS3, one of multiple forms of enzyme in brain | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | low activity | Rattus norvegicus | - |
| brain | most abundant in | Rattus norvegicus | - |
| kidney | low activity | Rattus norvegicus | - |
| lung | low activity | Rattus norvegicus | - |
| small intestine | low activity | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 4.62 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + arachidonate + CoA | - |
Rattus norvegicus | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
| ATP + eicosapentaenoate + CoA | - |
Rattus norvegicus | AMP + diphosphate + eicosapentaenoyl-CoA | - |
? | |
| ATP + laurate + CoA | - |
Rattus norvegicus | AMP + diphosphate + lauroyl-CoA | - |
? | |
| ATP + long-chain carboxylic acid + CoA | utilizes laurate and myristate most efficientyl among C8-C22 saturated fatty acids and arachidonate and eicosapentaenoate among the C16-C20 unsaturated fatty acids | Rattus norvegicus | AMP + diphosphate + long-chain acyl-CoA | - |
? | |
| ATP + long-chain carboxylic acid + CoA | the presence in the brain of multiple forms of enzyme with different fatty acid specificity is of considerable biological significance for controlling the synthesis of brain lipids. ACS3 mRNA is detectable 5 days after birth, increases to a maximum level at 15 days, and then decreases gradually to 10% of its maximum level in the adult | Rattus norvegicus | ? | - |
? | |
| ATP + myristate + CoA | - |
Rattus norvegicus | AMP + diphosphate + myristoyl-CoA | - |
? | |
| ATP + palmitate + CoA | - |
Rattus norvegicus | AMP + diphosphate + palmitoyl-CoA | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | - |
Rattus norvegicus |
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