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Literature summary for 6.2.1.3 extracted from

  • Klaus, C.; Jeon, M.K.; Kaemmerer, E.; Gassler, N.
    Intestinal acyl-CoA synthetase 5: activation of long chain fatty acids and behind (2013), World J. Gastroenterol., 19, 7369-7373.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.3

Inhibitors

Inhibitors Comment Organism Structure
Triacsin C i.e. 1-hydroxy-3-(E,E,E-2',4',7'-undecatrienylidine)triazene, potent competitive inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a long-chain fatty acid + CoA Homo sapiens
-
 AMP + diphosphate + a long-chain fatty acyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
enterocyte highest expression level in enterocytes at the villus tip Homo sapiens
-
small intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a long-chain fatty acid + CoA
-
 Homo sapiens AMP + diphosphate + a long-chain fatty acyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACSL5
-
 Homo sapiens
acyl-CoA synthetase 5
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens adenocarcinomas with an invasive phenotype and enhanced proliferation show decreased levels of isoform ACSL5 down

General Information

General Information Comment Organism
metabolism acyl-CoA synthetase 5 plays a key role in fatty acid metabolism. Isoform ACSL5 plays a role in channelling fatty acids towards palmitoylation and other lipid functions with high relevance for cellular behaviour Homo sapiens