Literature summary for 6.2.1.3 extracted from

Chang, Y.S.; Tsai, C.T.; Huangfu, C.A.; Huang, W.Y.; Lei, H.Y.; Lin, C.F.; Su, I.J.; Chang, W.T.; Wu, P.H.; Chen, Y.T.; Hung, J.H.; Young, K.C.; Lai, M.D.
ACSL3 and GSK-3beta are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells (2011), J. Cell. Biochem., 112, 881-893.

Search for more literature for 6.2.1.3

Cloned(Commentary)

Cloned (Comment)	Organism
gene acs-3, quantitative reverse transcription PCR expression analysis	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Triacsin C	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Homo sapiens	5783	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Huh-7 cell	-	Homo sapiens	-
liver	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
ACSL	-	Homo sapiens
ACSL3	-	Homo sapiens
long-chain acyl-CoA synthetase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	GSK-3beta inhibitors attenuate ACSL3 expression and the lipid accumulation induced by ER stress in HuH-7 cells. shRNA that target GSK-3beta also inhibits the upregulation of ACSL3 and lipid accumulation in HuH-7 and HepG2 cells	down
Homo sapiens	expression of ACSL3 is induced by ER stress in HuH-7 cells. shRNA that target GSK-3beta also inhibits the upregulation of ACSL3 and lipid accumulation in HuH-7 and HepG2 cells	up

General Information

General Information	Comment	Organism
physiological function	ACSL3 shRNA, but not ACSL1 shRNA, inhibits the induction of lipid accumulation	Homo sapiens

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Release 2023.1 (January 2023)