Literature summary for 6.2.1.3 extracted from

Marszalek, J.R.; Kitidis, C.; Dararutana, A.; Lodish, H.F.
Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth (2004), J. Biol. Chem., 279, 23882-23891.

Search for more literature for 6.2.1.3

Cloned(Commentary)

Cloned (Comment)	Organism
expression of isoenzyme ACS1 in PC12 cells. Overexpression of ACS1 increases the rate of oleic acid internalization by 55%, and arachidonic acid and docosahexaenoic acid uptake is increased by 25%, but there is no significant change in neurite outgrowth	Rattus norvegicus
expression of isoenzyme ACS2 in PC12 cells. Overexpression of ACS2 increases the rate of oleic acid internalization by 90%, arachidonic acid by 115%, docosahexaenoic acid by 70%. ACS2 enhances neurote outgrowth by promoting polyunsaturated fatty acid internalization	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P33124	isoenzyme ACS2	-
Rattus norvegicus	P33124	isoenzyme ACS1	-

Synonyms

Synonyms	Comment	Organism
ACS1	-	Rattus norvegicus
ACS2	-	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)