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Literature summary for 6.2.1.3 extracted from

  • Lewin, T.M.; Kim, J.H.; Granger, D.A.; Vance, J.E.; Coleman, R.A.
    Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently (2001), J. Biol. Chem., 276, 24674-24679.
    View publication on PubMed
Search for more literature for 6.2.1.3

Inhibitors

Inhibitors Comment Organism Structure
NEM ACS4 Rattus norvegicus
triacsin competitive inhibitor of both ACS1 and ACS4 Rattus norvegicus
troglitazone ACS4 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol ACS1 Rattus norvegicus 5829
-
endoplasmic reticulum ACS1 Rattus norvegicus 5783
-
membrane mitochondria-associated membrane, ACS1, ACS4 Rattus norvegicus 16020
-
mitochondrion mitochondrial membrane, ACS5. ACS1 is not detected in mitochondria Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus ACS1, ACS4 and ACS5 are regulated independently by fasting and refeeding. Fasting rats for 48 h results in a decrease in ACS4 protein and an increase in ACS5. ACS1 and ACS4 may be functionally channeled to specific metabolic pathways though different ACS isoforms in unique subcellular locations ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + palmitate + CoA
-
 Rattus norvegicus AMP + diphosphate + palmitoyl-CoA
-
 ?
additional information ACS1, ACS4 and ACS5 are regulated independently by fasting and refeeding. Fasting rats for 48 h results in a decrease in ACS4 protein and an increase in ACS5. ACS1 and ACS4 may be functionally channeled to specific metabolic pathways though different ACS isoforms in unique subcellular locations Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ACS1
-
 Rattus norvegicus
ACS4
-
 Rattus norvegicus
ACS5
-
 Rattus norvegicus