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Literature summary for 6.2.1.17 extracted from

  • Han, S.J.; Park, S.W.; Park, B.W.; Sim, S.J.
    Selective production of epothilone B by heterologous expression of propionyl-CoA synthetase in Sorangium cellulosum (2008), J. Microbiol. Biotechnol., 18, 135-137.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene prpE, functional expression in Sorangium cellulosum So ce90 leading to a significant increase in the resolution of epothilones B/A, with an epothilone B to A ratio of 127 to 1, which is 100times higher than that of the wild-type cells Ralstonia solanacearum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Ralstonia solanacearum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + propanoate + CoA Ralstonia solanacearum propionyl-CoA is a potent precursor of epothilone B, a potential anti-cancer agent AMP + diphosphate + propanoyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Ralstonia solanacearum
-
gene prpE
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + propanoate + CoA
-
Ralstonia solanacearum AMP + diphosphate + propanoyl-CoA
-
?
ATP + propanoate + CoA propionyl-CoA is a potent precursor of epothilone B, a potential anti-cancer agent Ralstonia solanacearum AMP + diphosphate + propanoyl-CoA
-
?

Synonyms

Synonyms Comment Organism
Propionyl-CoA synthetase
-
Ralstonia solanacearum

Cofactor

Cofactor Comment Organism Structure
ATP
-
Ralstonia solanacearum