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Literature summary for 6.2.1.17 extracted from
- The activation of short-chain fatty acids by the soluble fraction of guinea-pig heart and liver mitochondria. The search for a distinct propionyl-CoA synthetase (1975), Biochim. Biophys. Acta, 380, 12-20.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Butyrate | inhibits propanoate activation | Cavia porcellus |  |
| Octanoate | inhibits propanoate activation and butyrate activation | Cavia porcellus | |
| propanoate | inhibits acetate activation and butyrate activation | Cavia porcellus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.6 | - |
propanoate | - |
Cavia porcellus | |
| 5.4 | - |
Butyrate | - |
Cavia porcellus | |
| 11 | - |
acetate | - |
Cavia porcellus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Cavia porcellus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Cavia porcellus | - |
| additional information | heart: no distinct propanoyl-CoA synthetase is present | Cavia porcellus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetate + CoA | - |
Cavia porcellus | AMP + diphosphate + acetyl-CoA | - |
? | |
| ATP + butyrate + CoA | - |
Cavia porcellus | AMP + diphosphate + butyryl-CoA | - |
? | |
| ATP + propanoate + CoA | - |
Cavia porcellus | AMP + diphosphate + propanoyl-CoA | - |
? | |
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Release 2023.1 (January 2023)
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