Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.2.1.17 extracted from

  • Krahenbuhl, S.; Brass, E.P.
    Inhibition of hepatic propionyl-CoA synthetase activity by organic acids (1991), Biochem. Pharmacol., 41, 1015-1023.
    View publication on PubMed
Search for more literature for 6.2.1.17

Inhibitors

Inhibitors Comment Organism Structure
4-nitrobenzoate inhibition of propanoyl-CoA formation in solubilized mitochondria Rattus norvegicus
Butyrate inhibition of propanoyl-CoA formation in solubilized mitochondria Rattus norvegicus
Octanoate inhibition of propanoyl-CoA formation in solubilized mitochondria Rattus norvegicus
salicylate inhibition of propanoyl-CoA formation in solubilized mitochondria Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + propanoate + CoA Rattus norvegicus intracellular accumulation of propanoyl-CoA is associated with impairment of important heptic metabolic pathways. Since propanoate absorbed from the intestine can be converted to propanoyl-CoA in the liver, inhibition of propanoyl-CoA synthesis from propanoate and CoA may provide a strategy for decreasing toxicity from plasma propanoate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + propanoate + CoA
-
 Rattus norvegicus AMP + diphosphate + propanoyl-CoA
-
 ?
ATP + propanoate + CoA intracellular accumulation of propanoyl-CoA is associated with impairment of important heptic metabolic pathways. Since propanoate absorbed from the intestine can be converted to propanoyl-CoA in the liver, inhibition of propanoyl-CoA synthesis from propanoate and CoA may provide a strategy for decreasing toxicity from plasma propanoate Rattus norvegicus ?
-
 ?