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Literature summary for 6.2.1.1 extracted from

  • Doukov, T.I.; Blasiak, L.C.; Seravalli, J.; Ragsdale, S.W.; Drennan, C.L.
    Xenon in and at the end of the tunnel of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase (2008), Biochemistry, 47, 3474-3483.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ CODH/ACS uses a Ni-Fe-S center called the C-cluster to reduce carbon dioxide to carbon monoxide and uses a second Ni-Fe-S center, called the A-cluster, to assemble acetyl-CoA from a methyl group, coenzyme A, and C-cluster-generated CO Moorella thermoacetica
additional information the enzyme uses seven metalloclusters in four reaction steps, overview Moorella thermoacetica

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
310000
-
-
Moorella thermoacetica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Moorella thermoacetica CODH/ACS is a bifunctional enzyme that is responsible for the reduction of CO2 to CO and subsequent assembly of acetyl-CoA, as part of the Wood-Ljungdahl carbon fixation pathway, the enzyme is a key player in the global carbon cycle ?
-
?

Organism

Organism UniProt Comment Textmining
Moorella thermoacetica
-
formerly Clostridium thermoaceticum strain ATCC 39073
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CODH/ACS is a bifunctional enzyme that is responsible for the reduction of CO2 to CO and subsequent assembly of acetyl-CoA, as part of the Wood-Ljungdahl carbon fixation pathway, the enzyme is a key player in the global carbon cycle Moorella thermoacetica ?
-
?
additional information the enzyme is a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase, Moorella thermoacetica CODH/ACS contains a very long enzyme channel to allow for intermolecular CO transport, mechanism and reaction steps, overview. Structure-function analysis in comparison to monofunctional Acs, overview Moorella thermoacetica ?
-
?

Subunits

Subunits Comment Organism
More Moorella thermoacetica CODH/ACS contains a very long enzyme channel to allow for intermolecular CO transport, overview Moorella thermoacetica
tetramer alpha2beta2 Moorella thermoacetica

Synonyms

Synonyms Comment Organism
carbon monoxide dehydrogenase/acetyl-CoA synthase
-
Moorella thermoacetica
mtCODH/ACS
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Moorella thermoacetica