Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F244A | the mutant shows 90% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
F244A/I245A | the mutant shows 90% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
I245A | the mutant shows wild type aminoacylation activity | Homo sapiens |
I246D | the mutant shows 60% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
I246D/R247A | the mutant shows 20% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
I250D | the mutant shows 40% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
I250D/I251D | the mutant shows 20% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
I251D | the mutant shows 40% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
I254D | the mutant shows 40% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
I254D/R255A | the mutant shows 30% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
K249A | the mutant shows 90% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
R247A | the mutant shows 30% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
R255A | the mutant shows 40% aminoacylation activity compared to the wild type enzyme | Homo sapiens |
S248D | the mutant shows wild type aminoacylation activity | Homo sapiens |
S248D/K249A | the mutant shows wild type aminoacylation activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-lysine + tRNALys | Homo sapiens | - |
AMP + diphosphate + L-lysyl-tRNALys | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-lysine + tRNALys | - |
Homo sapiens | AMP + diphosphate + L-lysyl-tRNALys | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LysRS | - |
Homo sapiens |
Lysyl-tRNA synthetase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |