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Literature summary for 6.1.1.6 extracted from

  • Cen, S.; Khorchid, A.; Javanbakht, H.; Gabor, J.; Stello, T.; Shiba, K.; Musier-Forsyth, K.; Kleiman, L.
    Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1 (2001), J. Virol., 75, 5043-5048.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm cytoplasmic isozyme Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
62000 63000 isozyme packaged into virions, proteolytically truncated, gel filtration Homo sapiens
70000
-
cytoplasmic isozyme, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-lysine + tRNALys Homo sapiens
-
AMP + L-lysyl-tRNALys + diphosphate
-
?
additional information Homo sapiens enzyme is selectively packaged into virions during assembly of the human immunodeficiency virus type 1, i.e. HIV-1, through interaction with the viral Pr55gag protein, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
overexpressed and purified His-tagged enzyme from Escherichia coli
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification prior of packing of the enzyme into viral particles, it is truncated independent of viral protease Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-lysine + tRNALys
-
Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
-
?
additional information enzyme is selectively packaged into virions during assembly of the human immunodeficiency virus type 1, i.e. HIV-1, through interaction with the viral Pr55gag protein, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
L-Lysine-transfer RNA ligase
-
Homo sapiens
Lysine translase
-
Homo sapiens
Lysine--tRNA ligase
-
Homo sapiens
Lysine-tRNA synthetase
-
Homo sapiens
LysRS
-
Homo sapiens
Lysyl-transfer ribonucleate synthetase
-
Homo sapiens
Lysyl-transfer RNA synthetase
-
Homo sapiens
Lysyl-tRNA synthetase
-
Homo sapiens
Synthetase, lysyl-transfer ribonucleate
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens