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Literature summary for 6.1.1.6 extracted from
- Characterization of a homogeneous complex of arginyl- and lysyl-tRNA synthetase. Zinc and adenosine 5'-phosphate dependent synthesis of diadenosine 5',5'''-P1,P4-tetraphosphate (1983), Biochemistry, 22, 4353-4357.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| AMP | stimulation of diadenosine 5',5'''-P1,P4-tetraphosphate synthetase activity | Rattus norvegicus |  |
| Diphosphatase | stimulation of diadenosine 5',5'''-P1,P4-tetraphosphate synthetase activity | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.5 | - |
AMP | 5',5'''-P1,P4-tetraphosphate formation | Rattus norvegicus | |
| 2.1 | - |
ATP | 5',5'''-P1,P4-tetraphosphate formation | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | stimulation of diadenosine 5',5'''-P1,P4-tetraphosphate synthetase activity | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AMP + ATP | - |
Rattus norvegicus | diadenosine 5',5''-P1,P4-tetraphosphate + ? | - |
? | |
| ATP + lysine + tRNALys | - |
Rattus norvegicus | AMP + L-lysyl-tRNALys + diphosphate | - |
? | |
| additional information | L-lysine-dependent synthesis of 5',5'-diadenosine tetraphosphate (Ap4A) | Rattus norvegicus | ? | - |
? | |
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