Application | Comment | Organism |
---|---|---|
drug development | isoleucine utilization is an essential pathway that can be targeted for antimalarial drug development | Plasmodium falciparum |
Cloned (Comment) | Organism |
---|---|
genotyping of thiaisoleucine-resistant enzymes, expression of GFP-tagged cytoplasmic isozyme in erythrocytic stage parasite | Plasmodium falciparum |
Protein Variants | Comment | Organism |
---|---|---|
L810F | naturally occuring mutation in the cytoplasmic IleRS responsible for thiaisoleucine-resistance in the parasite, phenotype, overview | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
mupirocin | irreversible inhibition, inhibits development of invasion-competent parasites in the second asexual cycle, delayed death phenotype | Plasmodium falciparum | |
thiaisoleucine | directly competes with isoleucine for a target, irreversible inhibition, inhibits ring-stage parasites in development | Plasmodium falciparum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
apicoplast | - |
Plasmodium falciparum | 20011 | - |
cytoplasm | - |
Plasmodium falciparum | 5737 | - |
additional information | two IRS isozymes localize to distinct compartments in the parasite | Plasmodium falciparum | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
two isozymes, an apicoplast isozyme encoded by gene PFL1210w, and a cytoplasmic isozyme encoded by gene PF13_0179 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the cytoplasmic isozyme gene is expressed during the erythrocytic stages and is localized in the proper compartment for the bulk of protein synthesis, while the apicoplast isozyme is expressed at low rates in the erythrocytic stage and gets more abundant in later developmental stages, overview | Plasmodium falciparum | - |
Synonyms | Comment | Organism |
---|---|---|
Isoleucyl-tRNA synthetase | - |
Plasmodium falciparum |
General Information | Comment | Organism |
---|---|---|
additional information | thiaisoleucine-resistant parasites possess a mutation in the cytoplasmic isoleucyl-tRNA synthetase, mutational analysis, overview | Plasmodium falciparum |