Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.5 extracted from

  • Paulander, W.; Andersson, D.I.; Maisnier-Patin, S.
    Amplification of the gene for isoleucyl-tRNA synthetase facilitates adaptation to the fitness cost of mupirocin resistance in Salmonella enterica (2010), Genetics, 185, 305-312.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.5

Cloned(Commentary)

Cloned (Comment) Organism
gene ileS, quantitative real-time PCR expression analysis Salmonella enterica

Protein Variants

Protein Variants Comment Organism
P184T naturally occuring mutation that restores fitness in mupirocin resistant strains Salmonella enterica
Q420H naturally occuring mutation that restores fitness in mupirocin resistant strains Salmonella enterica

Inhibitors

Inhibitors Comment Organism Structure
mupirocin Mup, an isoleucyl-adenylate analogue that inhibits the essential enzyme, isoleucyl-tRNA synthetase Salmonella enterica

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
 gene ileS
-

Synonyms

Synonyms Comment Organism
IleRS
-
 Salmonella enterica
Isoleucyl-tRNA synthetase
-
 Salmonella enterica

General Information

General Information Comment Organism
additional information in mupirocin-resistant strains, e.g. evolved strain C12 that carried several copies of ileS, the antibiotic resistance leads also to reduced growth rates, these can be restored by the organism via increased expression of the original mutant ileS gene, also improving fitness while maintaining resistance, a process of adaptation initiated by common amplifications and followed by later acquisition of rare point mutations. A point mutation in one copy relaxes selection and allows loss of defective ileS copies, overview. Model for genetic adaptation of cells to the growth limitation caused by their MupR, overview Salmonella enterica