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Literature summary for 6.1.1.5 extracted from

  • Kim, S.E.; Kim, S.Y.; KI, S.; Kang, T.; Lee, J.
    Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetase (2005), Bioorg. Med. Chem. Lett., 15, 3389-3393.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,3-dideoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate IC50: 0.0064 mM Escherichia coli
2-deoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate IC50: 0.28 mM Escherichia coli
3-deoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate IC50: 0.035 mM Escherichia coli
adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate IC50: 0.000265 mM Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-isoleucine + tRNAIle
-
Escherichia coli AMP + diphosphate + L-isoleucyl-tRNAIle
-
?

Synonyms

Synonyms Comment Organism
IleRS
-
Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000265
-
IC50: 0.000265 mM Escherichia coli adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate
0.0064
-
IC50: 0.0064 mM Escherichia coli 2,3-dideoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate
0.035
-
IC50: 0.035 mM Escherichia coli 3-deoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate
0.28
-
IC50: 0.28 mM Escherichia coli 2-deoxy-adenosine-5-[(2S,3S)-2-amino-3-methylpentanoyl]-sulfamate