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Literature summary for 6.1.1.21 extracted from

  • Casciola-Rosen, L.
    Histidyl-transfer RNA synthetase: A key participant in idiopathic inflammatory myopathies (2011), Arthritis Rheum., 63, 331-333.
    View publication on PubMed
Search for more literature for 6.1.1.21

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
lung
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 Mus musculus
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lung
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 Homo sapiens
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muscle
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 Mus musculus
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muscle
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
HisRS
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 Mus musculus
HisRS
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 Homo sapiens
histidyl-transfer RNA synthetase
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 Mus musculus
histidyl-transfer RNA synthetase
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 Homo sapiens
Jo-1
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 Homo sapiens

General Information

General Information Comment Organism
additional information in idiopathic inflammatory myopathy, the aminoacyl-transfer RNA synthetases are targets of the autoimmune response. Among these antigens, antibodies against histidyl-transfer RNA synthetase are by far the most prominent found in 15-20% of myositis patients, and more strikingly, are detected in about 70% of patients with myositis and interstitial lung disease. Strong association of HisRS with interstitial lung disease in humans Homo sapiens
additional information mouse HisRS without adjuvant, containing Toll-like receptor TLR-4, can induce sustained muscle inflammation and an adaptive immune response to HisRS. Mice lacking TLR-4 show that the ability of mouse HisRS to produce muscle inflammation does not require TLR-4 signaling, nor is it dependent on recognition of B cell and T cell receptors. When TLR-4-deficient animals are immunized with HisRS, they have a preserved inflammatory response in muscle but fail to generate a HisRS antibody response Mus musculus