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Literature summary for 6.1.1.20 extracted from

  • Reshetnikova, L.; Moor, N.; Lavrik, O.; Vassylyev, D.G.
    Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue (1999), J. Mol. Biol., 287, 555-568.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme complexed with phenylalanine or the phenylalanyl-adenylate analogue phenylalaninyl-adenylate, X-ray diffraction structure determination at 2.7 and 2.5 A resolution, respectively, and analysis Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-phenylalanine + tRNAPhe Thermus thermophilus
-
AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
?

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
-
class II enzyme
-

Reaction

Reaction Comment Organism Reaction ID
ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe mechanism, the reaction intermediate is bound to the active site cleft in the catalytic alpha-subunit Thermus thermophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-phenylalanine + tRNAPhe
-
Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
?
ATP + L-phenylalanine + tRNAPhe the recognition of Phe through a mixture of van der Waals interactions and hydrogen bonds Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
?

Synonyms

Synonyms Comment Organism
CML33
-
Thermus thermophilus
FRS
-
Thermus thermophilus
HSPC173
-
Thermus thermophilus
L-Phenylalanyl-tRNA synthetase
-
Thermus thermophilus
Phenylalanine translase
-
Thermus thermophilus
Phenylalanine--tRNA ligase
-
Thermus thermophilus
Phenylalanine-tRNA synthetase
-
Thermus thermophilus
Phenylalanyl transfer ribonucleic acid synthetase
-
Thermus thermophilus
Phenylalanyl-transfer ribonucleate synthetase
-
Thermus thermophilus
Phenylalanyl-transfer RNA ligase
-
Thermus thermophilus
Phenylalanyl-transfer RNA synthetase
-
Thermus thermophilus
Phenylalanyl-tRNA ligase
-
Thermus thermophilus
Phenylalanyl-tRNA synthetase
-
Thermus thermophilus
PheRS
-
Thermus thermophilus
Synthetase, phenylalanyl-transfer ribonucleate
-
Thermus thermophilus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Thermus thermophilus