Literature summary for 6.1.1.17 extracted from

Desjardins, M.; Garneau, S.; Desgagnes, J.; Lacoste, L.; Yang, F.; Lapointe, J.; Chenevert, R.
Glutamyl adenylate analogs are inhibitors of glutamyl-tRNA synthetase (1998), Bioorg. Chem., 26, 1-13.

No PubMed abstract available

Search for more literature for 6.1.1.17

Inhibitors

Inhibitors	Comment	Organism	Structure
glutamyl adenylate	-	Escherichia coli
glutamyl cytidylate	weak inhibition	Escherichia coli
glutamyl dihydrocytidylate	very weak inhibition	Escherichia coli
glutamyl N6-benzoyladenylate	-	Escherichia coli
glutamyl uridylate	very weak inhibition	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-glutamate + tRNAGlu	Escherichia coli	-	AMP + diphosphate + L-glutamyl-tRNAGlu	-	r

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	pure enzyme	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-glutamate + tRNAGlu	-	Escherichia coli	AMP + diphosphate + L-glutamyl-tRNAGlu	-	r

Synonyms

Synonyms	Comment	Organism
GluRS	-	Escherichia coli
Glutamyl-tRNA synthetase	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Escherichia coli

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.003	-	glutamyl adenylate	37°C	Escherichia coli
0.06	-	glutamyl N6-benzoyladenylate	37°C	Escherichia coli
0.63	-	glutamyl cytidylate	37°C	Escherichia coli
2.75	-	glutamyl uridylate	37°C	Escherichia coli
16.7	-	glutamyl dihydrocytidylate	37°C	Escherichia coli

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Release 2023.1 (January 2023)