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Literature summary for 6.1.1.15 extracted from

  • Yu, X.Y.; Hill, J.M.; Yu, G.; Yang, Y.; Kluge, A.F.; Keith, D.; Finn, J.; Gallant, P.; Silverman, J.; Lim, A.
    A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase (2001), Bioorg. Med. Chem. Lett., 11, 541-544.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(2-chloro-thiophene)-4-quinolinecarboxylic acid
-
Candida albicans
2-(2-chloro-thiophene)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(3,4-dichloro-phenyl)-4-quinolinecarboxylic acid
-
Candida albicans
2-(3,4-dichloro-phenyl)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(4-bromo-phenyl)-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(4-bromo-phenyl)-5,7-dichloro-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-5,7-dichloro-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(4-bromo-phenyl)-5-methyl-7-chloro-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-5-methyl-7-chloro-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(4-bromo-phenyl)-6,8-dimethyl-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-6,8-dimethyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(4-bromo-phenyl)-6-(4-hydroxyphenyl)-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-6-(4-hydroxyphenyl)-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-bromo-phenyl)-6-(trifluoromethoxy)-4-quinolinecarboxylic acid strong inhibition Candida albicans
2-(4-bromo-phenyl)-6-(trifluoromethoxy)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(4-bromo-phenyl)-6-alkenyl-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-6-alkenyl-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-bromo-phenyl)-6-amino-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-6-amino-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-bromo-phenyl)-6-bromo-4-quinolinecarboxylic acid strong inhibition Candida albicans
2-(4-bromo-phenyl)-6-bromo-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-bromo-phenyl)-6-bromo-8-(trifluoromethyl)-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-6-bromo-8-(trifluoromethyl)-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-bromo-phenyl)-6-chloro-4-quinolinecarboxylic acid strong inhibition Candida albicans
2-(4-bromo-phenyl)-6-chloro-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-bromo-phenyl)-6-chloro-8-hydroxymethyl-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-6-chloro-8-hydroxymethyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid best inhibitor, species-selective Candida albicans
2-(4-bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-bromo-phenyl)-6-iodo-4-quinolinecarboxylic acid strong inhibition Candida albicans
2-(4-bromo-phenyl)-6-iodo-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(4-bromo-phenyl)-6-methyl-8-chloro-4-quinolinecarboxylic acid strong inhibition Candida albicans
2-(4-bromo-phenyl)-6-methyl-8-chloro-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-bromo-phenyl)-7-bromo-8-methyl-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-7-bromo-8-methyl-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-bromo-phenyl)-7-fluoro-8-methyl-4-quinolinecarboxylic acid
-
Candida albicans
2-(4-bromo-phenyl)-7-fluoro-8-methyl-4-quinolinecarboxylic acid
-
Homo sapiens
2-(4-methoxy-phenyl)-4-quinolinecarboxylic acid weak inhibition Candida albicans
2-(4-methoxy-phenyl)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-(4-[trifluoromethyl]-phenyl)-4-quinolinecarboxylic acid weak inhibition Candida albicans
2-(4-[trifluoromethyl]-phenyl)-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-furyl-4-quinolinecarboxylic acid weak inhibition Candida albicans
2-furyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-naphthyl-4-quinolinecarboxylic acid
-
Candida albicans
2-naphthyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-phenyl-4-quinolinecarboxylic acid weak inhibition Candida albicans
2-phenyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens
2-pyridyl-4-quinolinecarboxylic acid weak inhibition Candida albicans
2-pyridyl-4-quinolinecarboxylic acid weak inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-proline + tRNAPro Homo sapiens
-
AMP + diphosphate + L-prolyl-tRNAPro
-
?
ATP + L-proline + tRNAPro Candida albicans
-
AMP + diphosphate + L-prolyl-tRNAPro
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-proline + tRNAPro
-
Homo sapiens AMP + diphosphate + L-prolyl-tRNAPro
-
?
ATP + L-proline + tRNAPro
-
Candida albicans AMP + diphosphate + L-prolyl-tRNAPro
-
?

Synonyms

Synonyms Comment Organism
Global RNA synthesis factor
-
Homo sapiens
Global RNA synthesis factor
-
Candida albicans
Pro-tRNA synthetase
-
Homo sapiens
Pro-tRNA synthetase
-
Candida albicans
Proline translase
-
Homo sapiens
Proline translase
-
Candida albicans
Proline--tRNA ligase
-
Homo sapiens
Proline--tRNA ligase
-
Candida albicans
Prolyl RNA synthetase
-
Homo sapiens
Prolyl RNA synthetase
-
Candida albicans
Prolyl-transfer ribonucleate synthetase
-
Homo sapiens
Prolyl-transfer ribonucleate synthetase
-
Candida albicans
Prolyl-transfer ribonucleic acid synthetase
-
Homo sapiens
Prolyl-transfer ribonucleic acid synthetase
-
Candida albicans
Prolyl-transfer RNA synthetase
-
Homo sapiens
Prolyl-transfer RNA synthetase
-
Candida albicans
Prolyl-tRNA synthetase
-
Homo sapiens
Prolyl-tRNA synthetase
-
Candida albicans
ProRS
-
Homo sapiens
ProRS
-
Candida albicans

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Candida albicans

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Candida albicans