Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.12 extracted from

  • Berthet-Colominas, C.; Seignovert, L.; Hartlein, M.; Grotli, M.; Cusack, S.; Leberman, R.
    The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid (1998), EMBO J., 17, 2947-2960.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.12

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme complexed with a non-hydrolysable analogue of asparaginyl-adenylate and with ATP, X-ray diffraction structure determination at 2.6 A resolution Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-aspartate + tRNAAsp Thermus thermophilus
-
 AMP + diphosphate + L-aspartyl-tRNAAsp
-
 ?
additional information Thermus thermophilus aspartyl- and asparaginyl-tRNA synthetases have evolved relatively recently from a comon ancestor ?
-
 ?

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
-
 class IIb aminoacyl-tRNA synthetase
-

Reaction

Reaction Comment Organism Reaction ID
ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp active site residues Thermus thermophilus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-aspartate + tRNAAsp
-
 Thermus thermophilus AMP + diphosphate + L-aspartyl-tRNAAsp
-
 ?
additional information aspartyl- and asparaginyl-tRNA synthetases have evolved relatively recently from a comon ancestor Thermus thermophilus ?
-
 ?

Synonyms

Synonyms Comment Organism
Aspartic acid translase
-
 Thermus thermophilus
Aspartyl ribonucleate synthetase
-
 Thermus thermophilus
aspartyl ribonuleic synthetase
-
 Thermus thermophilus
Aspartyl-transfer ribonucleic acid synthetase
-
 Thermus thermophilus
Aspartyl-transfer RNA synthetase
-
 Thermus thermophilus
Aspartyl-tRNA synthetase
-
 Thermus thermophilus