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Literature summary for 6.1.1.10 extracted from

  • Ingvarsson, H.; Unge, T.
    Flexibility and communication within the structure of the Mycobacterium smegmatis methionyl-tRNA synthetase (2010), FEBS J., 277, 3947-3962.
    View publication on PubMed
Search for more literature for 6.1.1.10

Crystallization (Commentary)

Crystallization (Comment) Organism
monomeric MetRS in complex with the ligands methionine and adenosine or with methionine, X-ray diffraction structure determination and analysis at 2.3 A and 2.8 A resolution, respectively Mycolicibacterium smegmatis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mycolicibacterium smegmatis
Zn2+ binding domain and binding structure, overview Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + tRNAMet Mycolicibacterium smegmatis
-
 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + tRNAMet
-
 Mycolicibacterium smegmatis AMP + diphosphate + L-methionyl-tRNAMet
-
 ?
ATP + L-methionine + tRNAMet analysis of methionine and adenosine binding to MetRS, catalytic domain structure, overview. The KMSKS domain, residues 293-350, or stem contact fold domain, with a beta-alpha-alpha-beta-alpha topology domain, connects the catalytic domain with the anticodon domain, KMSKS domain conformation and structure, modelling, overview Mycolicibacterium smegmatis AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Subunits

Subunits Comment Organism
monomer MetRs is a monomeric multidomain enzyme, comparisons with other MetRS structures. The MetRS core unit consists of four domains: the catalytic domain, the CP domain, the KMSKS domain, and an anticodon-binding domain.the enzyme crystal structure contains a KMSKS(301-305) loop in proximity to the catalytic site in an open and inactive conformation, overview Mycolicibacterium smegmatis

Synonyms

Synonyms Comment Organism
methionyl-tRNA synthetase
-
 Mycolicibacterium smegmatis
MetRS
-
 Mycolicibacterium smegmatis

Cofactor

Cofactor Comment Organism Structure
ATP binding structure, overview Mycolicibacterium smegmatis