Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-(2,4-dichlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(2,4-dihydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(2,5-dichlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(2-chlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(2-hydroxyphenylformyloxyl)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(2-methoxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(2-methylphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(2-nitrophenylformyloxyl)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3,4-dichlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3,4-dihydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3,4-dimethoxyphenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3,5-dihydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3-bromophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3-chlorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3-chlorophenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3-chlorophenylformyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3-methylphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3-nitrophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3-pyridylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(3-trifluoromethylphenylformyoxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-bromophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-bromophenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-chlorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-chlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-fluorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-hydroxyphenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-hydroxyphenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-hydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-methylphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-nitrophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(6-hydroxynaphthalen-2-ylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(naphthalen-2-ylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-butyryloxyethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-hexanoyloxyethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-octanoyloxyethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-phenylacetyloxylethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tyrosine + tRNATyr | Staphylococcus aureus | - |
AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Staphylococcus aureus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tyrosine + tRNATyr | - |
Staphylococcus aureus | AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tyrosyl-tRNA synthetase | - |
Staphylococcus aureus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0009 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3-chlorophenylformyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | |
0.0011 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3-chlorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | |
0.0035 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3-bromophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | |
0.0043 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3-trifluoromethylphenylformyoxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0052 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-nitrophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0052 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(2,5-dichlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0057 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | |
0.0067 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3,5-dihydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0075 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-fluorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0079 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-hydroxyphenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | |
0.0088 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-chlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0093 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-chlorophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | |
0.0112 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-hydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0128 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-phenylacetyloxylethoxy)-3-phenylfuran-2(5H)-one | |
0.0165 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(2,4-dichlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0167 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-bromophenylacetyloxy)ethoxy)-3-(4-chlorophenyl)furan-2(5H)-one | |
0.0168 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(6-hydroxynaphthalen-2-ylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0177 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(naphthalen-2-ylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0178 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-methylphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0182 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(2-nitrophenylformyloxyl)ethoxy)-3-phenylfuran-2(5H)-one | |
0.026 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3-pyridylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0334 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3,4-dichlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.041 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-octanoyloxyethoxy)-3-phenylfuran-2(5H)-one | |
0.0414 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(2-hydroxyphenylformyloxyl)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0478 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-hexanoyloxyethoxy)-3-phenylfuran-2(5H)-one | |
0.0481 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-bromophenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0502 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(2,4-dihydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0568 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(2-chlorophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0647 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(2-methoxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0753 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3,4-dihydroxyphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.081 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3-methylphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0838 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3,4-dimethoxyphenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0846 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-butyryloxyethoxy)-3-phenylfuran-2(5H)-one | |
0.0936 | - |
in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-fluorophenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(2-methylphenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3-nitrophenylformyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(3-chlorophenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one | |
0.1 | - |
IC50 above 0.1 mM, in 100 mM Tris/Cl pH 7.9, 50 mM KCl, 16 mM MgCl2, at 37°C | Staphylococcus aureus | 4-(2-(4-hydroxyphenylacetyloxy)ethoxy)-3-phenylfuran-2(5H)-one |