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Literature summary for 5.4.99.23 extracted from
- RluD, a highly conserved pseudouridine synthase, modifies 50S subunits more specifically and efficiently than free 23S rRNA (2007), RNA, 13, 1868-1876.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 23S rRNA uridine1911/uridine1915/uridine1917 | Escherichia coli | RluD is far more efficient in modifying uridine residues in helix 69 in structured 50S subunits, compared to free or synthetic 23S rRNA. It is suggested that pseudouridine modifications in helix 69 are made late in the assembly of 23S rRNA into mature 50S subunits | 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P33643 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 23S rRNA uridine1911/uridine1915/uridine1917 | RluD is far more efficient in modifying uridine residues in helix 69 in structured 50S subunits, compared to free or synthetic 23S rRNA. It is suggested that pseudouridine modifications in helix 69 are made late in the assembly of 23S rRNA into mature 50S subunits | Escherichia coli | 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 | - |
? | |
| 23S rRNA uridine1911/uridine1915/uridine1917 | RluD is far more efficient in modifying uridine residues in helix 69 in structured 50S subunits, compared to free or synthetic 23S rRNA | Escherichia coli | 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RluD | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | RluD is a ribosomal assembly factor that may be involved in the late stages of maturation of the large ribosomal subunit | Escherichia coli |
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Release 2023.1 (January 2023)
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